UF-Membrane Refining and Impurity Removal System: Pharmaceutical-Grade Purification for Critical Flu

UF-Membrane Refining and Impurity Removal System: Pharmaceutical-Grade Purification for Critical Flu

Pharmaceutical-Grade Purity

Material Integrity

Energy Efficiency:

Zero Contamination Risk

Scalability

Cost Savings

Advanced Ultrafiltration Technology for Uncompromised Purity

Chlory UF-Membrane Refining and Impurity Removal System leveragesprecision ultrafiltration (UF) membrane technologyto achieve molecular-level separation of macromolecules, colloids, and microorganisms. Designed for pharmaceutical, biotechnology, and high-purity chemical applications, this system operates at ≤0.7 MPa pressure and ambient temperatures (5–45°C/75°C), eliminating thermal degradation risks while ensuring >99% removal of impurities. As a national high-tech enterprise with 40+ patents and 2,000+ industrial deployments, Xihe Flow guarantees compliance with pharmacopeia standards for critical processes like injectable purification and biologics desalination.

Process Flow: Molecular Sieving for Absolute Clarity

The UF system employs apressure-driven cross-flow filtration processthat separates impurities without chemical additives:

  1. Feed Pressurization: Raw material enters under controlled pressure (≤0.7 MPa).
  2. Selective Separation: UF membranes retain macromolecules (>1,000–500,000 Da), colloids, and microorganisms while allowing solvents and small molecules to permeate.
  3. Output Streams:

    • Retentate: Concentrated impurities (e.g., endotoxins, proteins) for disposal.

    • Permeate: Purified fluid ready for final formulation.

      Closed-loop, automated, and ISO-compliant operation.

The membrane separation process relies on precise molecular-level screening. Feed liquid containing water, small molecules, and large particles passes through semi-permeable membranes. Water and small molecules permeate, while large particles are retained as concentrate.

Key Advantages

  1. Pharmaceutical-Grade Purity: Removes >99% endotoxins, viruses, and colloids for injectables (e.g., WFI, monoclonal antibodies).
  2. Material Integrity: Gentle room-temperature processing preserves APIs, enzymes, and heat-sensitive compounds.
  3. Energy Efficiency: 70% lower energy consumption vs. centrifugation/diatomaceous earth filtration.
  4. Zero Contamination Risk: No chemical additives; fully autoclavable (SIP/CIP compatible).
  5. Scalability: Modular design supports capacities from 50 to 8,000 kg/h.
  6. Cost Savings: Membranes reusable for 2–3 years with cleanable surfaces.

Technical Specifications

Model Capacity (kg/h) Power (kW) Pressure (MPa) Temperature (°C)
XH-UF4040-1X 50–100 2.2 ≤0.7 5–45/75
XH-UF4040-2X 100–150 2.2 ≤0.7 5–45/75
XH-UF4040-4X 150–250 4.0 ≤0.7 5–45/75
XH-UF4040-6X 250–300 5.5 ≤0.7 5–45/75
XH-UF8040-1X 150–300 4.0 ≤0.7 5–45/75
XH-UF8040-2X 300–600 4.0 ≤0.7 5–45/75
XH-UF8040-4X 600–1,000 7.5 ≤0.7 5–45/75
XH-UF8040-6X 1,000–1,500 7.5 ≤0.7 5–45/75
XH-UF8040-8X 1,500–2,000 7.5 ≤0.7 5–45/75
XH-UF8040-9X 1,800–2,500 11 ≤0.7 5–45/75
XH-UF8040-12X 2,500–3,500 11 ≤0.7 5–45/75
XH-UF8040-15X 3,500–4,500 15 ≤0.7 5–45/75
XH-UF8040-16X 4,000–5,000 22 ≤0.7 5–45/75
XH-UF8040-18X 4,500–5,500 22 ≤0.7 5–45/75
XH-UF8040-20X 5,000–6,000 22 ≤0.7 5–45/75
XH-UF8040-24X 6,000–8,000 30 ≤0.7 5–45/75

Custom configurations available for specialized needs.

Industry Applications

  • Pharmaceuticals:

    • Purification of injections (e.g., double Coptis injection), oral liquids, and biologics.
    • Removal of pyrogens and aggregates in monoclonal antibodies.
  • Biotech:

    • Fermentation broth clarification and enzyme purification.
  • Food & Beverage:

    • Juice/wine clarification and stability enhancement.
  • Chemicals:

    • Polymer fractionation and catalyst recovery.
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