TCM Extract Membrane Filtration & Room Temperature Concentration Technology

Traditional Chinese medicines have extremely complex chemical components, including a variety of active ingredients, inactive ingredients, and even toxic components. Extracting, further separating and purifying active ingredients to obtain active monomers is an important research direction in the field of traditional Chinese medicine research.

TCM preparations are produced by extracting Chinese medicinal materials. The extract contains a large number of impurities such as plant proteins, plant starch, plant fibers, tannins and pigments. Clarification treatment with traditional filtration devices only achieves temporary clarification of the extract. Under the influence of temperature, time, electric charge and other factors, soluble macromolecular impurities such as proteins and tannins re-flocculate to form flocculent precipitates, causing drug deterioration, affecting product efficacy, greatly reducing product clarity and shortening the product shelf life.

With years of practical experience serving pharmaceutical enterprises and professional advantages in membrane separation technology, BluewavBio has successfully applied membrane filtration technology to the production process of TCM preparations. Relying on the precise interception effect of ultrafiltration membranes, it separates macromolecular impurities from TCM extracts, ensures the clarity of terminal preparations, improves drug quality and extends shelf life. Furthermore, by utilizing the dehydration and solvent removal functions of nanofiltration or reverse osmosis (RO) membranes, it can further concentrate TCM extracts at room temperature. At present, membrane separation technology has been widely applied in the production of TCM preparations.

BluewavBio has dozens of successful cases in the pharmaceutical industry, covering all provinces across China!

TCM Extract → Centrifugal Filtration → Ultrafiltration → Nanofiltration / Reverse Osmosis → Subsequent Processes

(1) Adopts world-class nano membrane materials with strong selective separation performance, thorough impurity separation, high filtrate clarity, no re-turbidity after long-term storage and no secondary precipitation;

(2) Greatly reduces solvent consumption in traditional processes, lowers explosion-proof grade and improves production safety;

(3) The material liquid operates in a unique cross-flow mode without adding filter aids, effectively solving membrane fouling and blockage problems;

(4) It is a pure physical process without chemical reactions, which does not change medicinal active ingredients, significantly improves product quality and enhances medication safety;

(5) The membrane system features a high degree of automation, controlled by PLC and frequency converters with simple operation;

(6) Equipped with automatic control, online regeneration cleaning and sewage discharge design, it reduces labor intensity and realizes clean production;

(7) The whole equipment is made of sanitary-grade materials, complying with GMP certification standards.

Honeysuckle, Astragalus, Panax Notoginseng, Coptis Chinensis, Desmodium Styracifolium, Dendrobium, Angelica Dahurica, Angelica, Ginseng, Scutellaria Baicalensis, Licorice, Bupleurum, Ginkgo, Ganoderma Lucidum, Schisandra Chinensis, etc.